Increased Estrogen Rather Than Decreased Androgen Action Is Associated with Longer Androgen Receptor CAG Repeats

Excerpt: The correlations of this polymorphism with various endocrine and phenotypic features of men have been exhaustively studied. Many, though not all of these studies, demonstrate inverse correlation of the repeat length with androgenicity, suggesting that men with longer repeats have weaker overall androgen action. The phenotypes found to correlate directly with the CAG repeat length include poor spermatogenesis and male-to-female transsexualism.

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